منابع مشابه
Nucleic acid carriers for pulmonary gene delivery
The delivery of nucleic acids to the pulmonary route appears to be promising due to non-invasiveness, large area of epithelial surface lining the lung, easy accessibility and ability to provide a platform for local delivery. The therapeutic role of nucleic acids in various diseases pertaining to the pulmonary route e.g. cystic fibrosis, α1-antitrypsin deficiency, asthma, chronic obstructive pul...
متن کاملApplication of polymers in nucleic acid delivery
Gene therapy and immunotherapy are powerful techniques in the treatment of many life threatening diseases. The major challenge in these therapies is to seek a safe and efficient delivery carrier for gene and antigen materials. Carriers are designed to protect these molecules from degradation, improve their stability and facilitate the delivery of them to the site of action. This research study ...
متن کاملTransformation and Nucleic Acid Delivery to Mitochondria
Two types of mt DNA are present in the embryophytes (land plants). The mitochon-dria of the three clades of bryophytes (liver-worts, hornworts and mosses, see chapter " Promiscuous Organellar DNA ") possess circular genomes of around 105–185 kb resembling that of their green algal relatives like Chara and even the early-branching nongreen eukaryote, Reclinomonas ameri-cana (Li et al. 2009). The...
متن کاملNucleic acid delivery with microbubbles and ultrasound.
Nucleic acid-based therapy is a growing field of drug delivery research. Although ultrasound has been suggested to enhance transfection decades ago, it took a combination of ultrasound with nucleic acid carrier systems (microbubbles, liposomes, polyplexes, and viral carriers) to achieve reasonable nucleic acid delivery efficacy. Microbubbles serve as foci for local deposition of ultrasound ener...
متن کاملDirected evolution for drug and nucleic acid delivery.
Directed evolution is a term used to describe a variety of related techniques to rapidly evolve peptides and proteins into new forms that exhibit improved properties for specific applications. In this process, molecular biology techniques allow the creation of up to billions of mutants in a single experiment, which are then subjected to high-throughput screening to identify those with enhanced ...
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ژورنال
عنوان ژورنال: Advanced Drug Delivery Reviews
سال: 2016
ISSN: 0169-409X
DOI: 10.1016/j.addr.2016.06.008